Church Fathers on Matthew 16:28

Because He had said, Whoso will save, shall lose, and whoso will lose shall save, opposing saving to losing, that none should hence conclude that there was any equality between the losing on one side, and the saving on the other, He adds, 'What does it profit a man, if he shall gain the whole world, but suffer the loss of his soul?' As though He had said, Say not that he who escapes the dangers which threaten him for Christ’s sake, saves his soul, that is, his temporal life;…

I suppose also that he gains the world who does not deny himself, nor loses his own life as to carnal pleasures, and thence suffers the loss of his soul. These two things being set before us, we must rather choose to lose the world, and gain our souls.

Or the connexion may be thus; The Holy Church has a period of persecution, and a period of peace; and our Redeemer accordingly distinguishes between these periods in His commands; in time of persecution the life is to be laid down; but in time of peace, those earthly lusts which might gain too great power over us are to be broken through; whence He says, 'What does it profit a man?'